The NOSTRADAMUS Study: Microvascular Dysfunction in Sepsis

A new study using GlycoCheck, and co-authored by GlycoCheck Chief Science Offer, Dr. Hans Vink, reports new findings of research on patients with sepsis. The study, titled “Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study” was published in Critical Care. Critical Care is a high-quality, peer-reviewed, international clinical medical journal that…

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Dietary Glycocalyx Precursor Supplementation Ameliorates Age‐Related Vascular Dysfunction

Abstract Large elastic artery stiffening and endothelial dysfunction, and associated reductions in nitric oxide (NO) bioavailability, are central features of vascular aging. We have recently demonstrated that the glycocalyx, a gel-like structure that is bound to the luminal surface of the vascular endothelium, is dysfunctional in the aged vasculature. The glycocalyx has several functions that are critical for the…

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Endocalyx: Pilot Study in 13 Healthy Volunteers

Summary of Findings from Clinical Studies 6.3.2 Food supplement A pilot study was conducted among 13 healthy volunteers receiving the Endocalyx food supplement. After 3 months, the Microvascular Health Index measured by SDF imaging improved by 31%. After 4 months, the Microvascular Health Index in the volunteers improved by 50%. This showed the beneficial effects of the food supplement…

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Dietary Interventions on Glycocalyx Dimensions in South Asian Patients With Diabetic Nephropathy. (Glycotreat)

Clinical Trial Study Sponsor: Leiden University Medical Center Collaborators: Dutch Kidney Foundation Health Holland Radboud University Subsidizing Party: Health Holland (Dutch Top Sector Life Sciences & Health) Laan van Nieuw Oost-Indië 334, 2593 CE Den Haag The Netherlands Dutch Kidney Foundation Groot Hertoginnelaan 34 1405 EE, Bussum The Netherlands Laboratory Sites: Leiden University Medical Center, The Netherlands Radboud University…

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Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study

Abstract Background: Deterioration of the endothelial glycocalyx (eGC), a protective carbohydrate-rich layer lining the luminal surface of the endothelium, plays a key role in vascular barrier dysfunction and eventually organ-failure in systemic inflammatory response syndrome and sepsis. Early detection of glycocalyx damage could thus become an important goal in critical care. This study was designed to determine the feasibility…

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Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion

Abstract Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial dysfunction and activation. Methods and Results We examined the sublingual glycocalyx noninvasively using sidestream dark field imaging in the third trimester among women with normotensive pregnancies (n=73), early (n=14)…

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Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis

Abstract Background: The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to capillary leak and organ dysfunction. Moreover, sepsis-induced alterations of sublingual microcirculation are associated with a worse clinical outcome. The present study was performed to investigate the associations…

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Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall

Abstract Objective: PBR characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation and other vascular parameters. The goal of our study was to reliably quantify PBR and assess its potential use as a new marker of cardiovascular pathology. Methods: The study included 208 patients (123 men and 85 women from 40…

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Adjunctive Treatment of Psychotic Disorders with Micronutrients

Abstract

Objective: To evaluate the effect of micronutrients (minerals and vitamins) on adult psychosis when added to conventional medications by using a placebo-controlled randomized design with a 1-month open-label run-in.

Design: Longitudinal comparison study following a randomized, controlled trial that had failed because participants declined to undergo randomization.

Setting/Locations: Rural primary care and psychiatry clinic in northern New England (town of 16,000…

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Hospitalization cost of conventional psychiatric care compared to broad-spectrum micronutrient treatment

Abstract

Background: Healthcare costs are skyrocketing, with mental health treatment amongst the most expensive, especially when hospitalization is involved. According to the Mental Health Commission of Canada, one in five Canadians is living with a mental disorder in any given year, at an annual cost of $50 billion. In light of this societal burden, alternative approaches are being evaluated, such…

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