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Study: Improving Aortic Aging with Endocalyx Pro

A new paper has been announced by NuLife Sciences and Microvascular Health Solutions, subsidiaries of Bioregenx. The paper reports that Endocalyx Pro™ increased glycocalyx thickness and decreased aortic stiffness in a study conducted by researchers at the University of Utah and Florida State University. The study, titled “Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction,” was published in GeroScience – Official Journal of the American Aging Association (AGE) and also included the use of GlycoCheck™, distributed exclusively by MVHS.

The researchers aimed to determine if changes in glycocalyx properties would affect arterial function in mice. They used tamoxifen-induced hyaluronan synthase 2 (Has2) reduction to decrease glycocalyx properties. Three weeks after tamoxifen treatment, glycocalyx thickness was lower in Has2 knockout mice compared to wild-type mice (P<0.05). Has2 reduction resulted in arterial dysfunction, as shown by impaired endothelium-dependent dilation (EDD) and increased aortic stiffness (P<0.05).

To improve glycocalyx properties, old mice were given 10 weeks of glycocalyx-targeted therapy with Endocalyx Pro™ (old+ECX), which contains HMW-HA and other glycocalyx components. Compared to old control mice, glycocalyx properties and EDD were improved and aortic stiffness was reduced in old+ECX mice (P<0.05). Old+ECX mice had a more youthful aortic phenotype, with lower collagen content and higher elastin content than old control mice (P<0.05).

“It is amazing to see that loss of vascular function that typically is associated with the long term effects of aging (such as stiffer larger arteries, thicker arterial walls, loss of capillaries, glycocalyx damage, reduced nitric oxide bioavailability and impaired vasodilation) can effectively be prevented by supplementing the diet with a natural therapeutic that is directed to protect and support the endothelial glycocalyx” said Dr. Hans Vink, Chief Science Officer of Microvascular Health Solutions. “Treatment of mice for only 10 weeks with Endocalyx, normalized both macrovascular function and microvascular properties compared with young mice, which indicated that the effects of old age on vascular health can be reversed in a relatively short period.”

The researchers wrote that “these findings suggest that the glycocalyx may be a viable therapeutic target to ameliorate age-related arterial dysfunction.”

Additional Endocalyx Studies Available

Several studies have been conducted on the use of Endocalyx Pro for improving microvascular health. These studies have focused on conditions and diseases such as COVID-19, stroke, diabetes, kidney disease, and aging. Additional research has been ongoing since 2015 on heart disease, sepsis, and psoriasis using cell cultures, animals, and humans. These studies can be found on Bioregenx.com for review.

Disclaimer Notice: The statements made in this article have not been evaluated by the Food and Drug Administration (FDA) or the Federal Trade Commission (FTC). This product is not intended to diagnose, treat, cure or prevent any disease. Consult your physician before using this or any other product.

Improve Vascular Health with This Supplement

The Science

The endothelial glycocalyx is a layer of sugar molecules that coats the inner lining of your blood vessels. It plays a vital role in maintaining vascular health by regulating blood flow, preventing blood clots, and protecting against inflammation.

As we age, the endothelial glycocalyx can become damaged, which can lead to a number of health problems, including heart disease, stroke, and type 2 diabetes.

There are a number of things you can do to protect your endothelial glycocalyx, including:

Eating a healthy diet that is low in processed foods, industrial seed (vegetable) oil and high in whole foods
Exercising regularly and appropriately for your capability
Maintaining a healthy weight to reduce stress on your liver and insulin levels
Avoiding smoking
Managing stress in a healthy way
Taking Endocalyx Pro

Dietary Supplements for Vascular Health

There are a number of dietary supplements that have been shown to support the health of the endothelial glycocalyx. These include:

Glucosamine sulfate is a natural compound that is found in the cartilage of joints. It has been shown to help protect the endothelial glycocalyx from damage. [1]
Fucoidan is a type of seaweed extract that has been shown to have anti-inflammatory and antioxidant properties. It can help to protect the endothelial glycocalyx from damage caused by free radicals. [2]
Superoxide dismutase (SOD) is an enzyme that helps to protect cells from damage caused by free radicals [3] which can be found in olive leaf extract [4]. It can help to protect the endothelial glycocalyx from damage.
High molecular weight hyaluronic acid is a type of sugar that helps to keep tissues hydrated and lubricated. It can help to protect the endothelial glycocalyx from damage [5].

Our dietary supplement, Endocalyx Pro, contains these key ingredients to improve and protect the function of the endothelial glycocalyx.

Talk to Your Doctor Before Taking Supplements

This article is not intended to diagnose or treat disease and has not been reviewed by the FDA. It is important to talk to your doctor before taking any dietary supplements, especially if you have any underlying health conditions. Some supplements may interact with medications or have other side effects.

Taking Control of Your Vascular Health

By making healthy lifestyle choices and taking a dietary supplements such as Endocalyx Pro, you can help to protect your endothelial glycocalyx and improve your vascular health.

Promising Supplement for Kidney Health: Fucoidan

The Science

Introduction
Endothelial glycocalyx is a layer of sugar molecules that lines the inside of blood vessels and protects them from damage. Chronic kidney disease (CKD) is a condition in which the kidneys are damaged and cannot filter blood as well as they should. Fucoidan is a sulfated polysaccharide found in brown seaweed and sold as a dietary supplement that has been shown to have anti-inflammatory, anti-tumor, and anti-viral properties[1]. Fucoidan is one of the primary ingredients found in our dietary supplement, Endocalyx Pro^TM. A recent study published in a special issue of International Journal of Molecular Sciences suggests that a dietary supplement containing fucoidan preserves endothelial glycocalyx through ERK/MAPK signaling and protects against damage induced by CKD serum. In this article, we’ll take a closer look at fucoidan and its potential benefits for people with CKD.

Chronic kidney disease is a serious health condition and requires medical diagnosis and treatment. This article does not intend to offer advice to diagnose or treat any health condition. You should always talk to your doctor for medical advice. Statements in this article have not been evaluated by the FDA.

What is endothelial glycocalyx?
Endothelial glycocalyx is a layer of sugar molecules that lines the inside of blood vessels and protects them from damage. It plays an important role in regulating blood flow and preventing blood clots. When the glycocalyx is damaged, it can lead to inflammation, oxidative stress, and other health problems[2].

What is fucoidan?
Fucoidan is a sulfated polysaccharide found in brown seaweed. It has been shown to have anti-inflammatory, anti-tumor, and anti-viral properties[1]. Fucoidan has also been found to have a number of other potential health benefits, including improving gut health, boosting the immune system, and reducing the risk of heart disease[3].

What is chronic kidney disease?
Chronic kidney disease (CKD) is a condition in which the kidneys are damaged and cannot filter blood as well as they should. This can lead to a buildup of waste products in the blood, which can cause a range of health problems. CKD is a common condition, affecting millions of people around the world.

How does fucoidan preserve endothelial glycocalyx?
According to the study in International Journal of Molecular Sciences, a dietary supplement containing fucoidan preserves endothelial glycocalyx through ERK/MAPK signaling and protects against damage induced by CKD serum.

How does fucoidan protect against damage induced by CKD serum?
The study suggests that fucoidan may also protect against damage induced by CKD serum. CKD serum is a type of blood serum that is associated with kidney damage. By protecting against this type of damage, fucoidan may help to improve kidney function and reduce the risk of complications associated with CKD such as heart disease and anemia.

How can the supplement be used to help people with chronic kidney disease?
The study also suggests that a supplement containing fucoidan could be used to help people with chronic kidney disease. Our Endocalyx Pro is a dietary supplement that contains fucoidan and is designed to support endothelial glycocalyx health. However, it’s important to note that more research is needed to determine the safety and effectiveness of fucoidan for this purpose. If you’re interested in trying Endocalyx Pro, it’s a good idea to talk to your doctor first to make sure it’s safe for you.

Conclusion
Fucoidan is a sulfated polysaccharide found in brown seaweed that has been shown to have anti-inflammatory, anti-tumor, and anti-viral properties. A recent study suggests that a dietary supplement containing fucoidan preserves endothelial glycocalyx through ERK/MAPK signaling and protects against damage induced by CKD serum. While more research is needed to determine the safety and effectiveness of fucoidan for people with CKD, it’s an interesting area of research that could lead to new treatments for this common condition. If you are interested in kidney health or trying Endocalyx Pro, talk to your doctor to see if it’s right for you.

Understanding Inositol, Insulin Resistance & Metabolic Health

The Science

Introduction to Insulin Resistance & Inositol

Understanding insulin resistance can be important to understanding your metabolic health. Understanding inositol and how it could affect insulin resistance could be as important. Insulin resistance is when the body’s cells do not respond well to insulin, a hormone that controls blood sugar levels. PCOS, type 2 diabetes, heart diseases are some of the health issues caused by insulin resistance. Inositol is a natural substance that is found in living cells and may help with cell communication and nerve function. Many people take inositol as a dietary supplement to improve their insulin sensitivity and prevent or treat related conditions¹. We will look at some of the scientific evidence that seems show that inositol may help with insulin resistance and other metabolic conditions¹. It should be noted that insulin resistance, metabolic syndrome, diabetes, and cardiovascular disease are serious health conditions and require medical diagnosis and treatment. This article does not intend to offer advice to diagnose or treat these health conditions. Please talk to your doctor if you think you have any of these conditions for professional medical advice.

These statements have not been evaluated by the FDA. This article’s primary purpose is to make you aware of potential uses of our bCalm dietary supplement.

Inositol works to mimic insulin and modulate insulin signaling

It seems clear from studies that those with insulin resistance can benefit from taking an inositol supplements on a regular basis^{1 2 3}. High blood sugar (glucose) can occur if you become insulin resistant because your body is not responding to insulin as it should. Inositol can act like insulin (e.g. mimic insulin) and help the cells take in and use glucose better. Inositol can also improve how insulin works by turning on the enzymes involved in insulin signaling⁴. The key take away is that inositol may make your body more sensitive to insulin.

Inositol improves blood sugar, insulin, and lipid levels

Inositol, when taken as a dietary supplement, may help those with metabolic issues such a high blood sugar, and high lipid levels in those with insulin resistance ⁴. The lipid levels associated with insulin resistance such as high triglycerides and oxidized LDL. Inositol can also help the body handle glucose better and prevent blood sugar spikes which is important to good metabolic health.

Inositol reduces the risk or severity of PCOS

Women with polycystic ovary syndrome (PCOS) have problems with their hormones, ministration, skin acne, and hair growth. They also have trouble getting pregnant. PCOS can be caused by insulin resistance. Taking an Inositol supplements may help women with PCOS by reducing insulin resistance and lowering their male hormone levels ⁵. Women with PCOS may also experience regular ministration and improved fertility with less insulin resistance⁵.

Wrapping up

Inositol is a sugar alcohol that helps your cell’s function and affects your brain chemicals and insulin. Taking inositol supplements may help with insulin resistance and related problems by improving how your cells use glucose and how your body regulates insulin and cholesterol. Inositol supplements may also help with PCOS by affecting hormone levels. However, you should talk to your doctor before taking an inositol supplement to make sure they are safe for you and won’t cause any intolerable side effects or interactions.

NuLife Sciences’ bCalm is a “nutraceutical” grade dietary supplement that corresponds 100% to inositol and could benefit those with insulin resistance. Click here to learn more!

Disclaimer Notice: The statements made in this article have not been evaluated by the Food and Drug Administration (FDA) or the Federal Trade Commission (FTC). This product is not intended to diagnose, treat, cure or prevent any disease. Consult your physician before using this or any other product.