Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomized placebo-controlled trial

Rucklidge JJ, Frampton CA, Gorman B, Boggis A
The British Journal of Psychiatry, January 30, 2014


Background: The role of nutrition in the treatment of attention-deficit hyperactivity disorder (ADHD) is gaining international attention; however, treatments have generally focused only on diet restriction or supplementing with one nutrient at a time.

Aim: To investigate the efficacy and safety of a broad-based micronutrient formula consisting mainly of vitamins and minerals, without omega fatty acids, in the treatment of ADHD in adults.

Method: Intent-to-treat analyses showed significant between-group differences favoring active treatment on self- and observer- but not clinician-ADHD rating scales. However, clinicians rated those receiving micronutrients as more improved than those on placebo both globally and on ADHD symptoms. Post hoc analyses showed that for those with moderate/severe depression at baseline, there was a greater change in mood favoring active treatment over placebo. There were no group differences in adverse events.

Conclusion: This study provides preliminary evidence of efficacy for micronutrients in the treatment of ADHD symptoms in adults, with a reassuring safety profile.